| Check out the first preprint from my postdoctoral work in St Andrews in the NCM Lab! I am particularly proud of what we managed to accomplish through this pandemic! In this work, we describe the differential expression of two inward currents (PIC and Ih) in fast and slow motoneurons, which are sequentially integrated during the first three weeks of postnatal development, and contribute to the establishment of their orderly recruitment. These results support the notion proposed long ago, that fast motoneurons are not simply scaled up slow motoneurons and our work provides insight into cellular mechanisms that mediate orderly recruitment beyond the size principle alone. I am excited to continue to dissect mechanisms that shape motoneuron recruitment, including how they can be modulated to support adaptable movement! |
Simon A. Sharples, PhD 