ABOUT ME

SIMON A. SHARPLES, PHD
Research Fellow
Crone Lab
Cincinnati Children’s Hospital

I am a Canadian postdoctoral fellow in the laboratory of Dr. Steven Crone at Cincinnati Children’s Hospital, and have been supported by prestigious international fellowships from the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Research (CIHR), and the Royal Society (Newton International Fellowship). In the Fall of 2026, I will be joining Pennsylvania State University as an Assistant Professor in the Department of Kinesiology, where I will hold the Dorothy Foehr Huck and J. Lloyd Huck Early Career Chair in the Huck Institute for Life Sciences.

My research program focuses on spinal circuit mechanisms controlling movement and breathing, with a central emphasis on gain control processes that regulate the intensity and precision of motor output. I investigate how these circuit mechanisms emerge during development as motor behaviors are established, and how they are disrupted following spinal cord injury and neurological disease.

Using a multidisciplinary toolkit in rodent models, my lab defines how spinal circuits generate flexible and adaptive motor output across development and disease, and identifies circuit-level mechanisms that can be targeted to restore movement and breathing function following injury.

I am committed to building a collaborative, interdisciplinary research program that integrates fundamental neuroscience with therapeutic discovery, alongside teaching motor systems physiology at both the undergraduate and graduate levels.


Professional profiles


Recently Published Work

Intrinsic mechanisms contributing to the biophysical signature of mouse gamma motoneurons (Published in The Journal of Physiology)

A cholinergic spinal pathway for the adaptive control of breathing (Published in Cell Reports)


Outside of the lab

In addition to being the primary focus of my research, movement is also an integral part of my life. I am an avid angler and outdoor enthusiast. When I’m not in the lab you can find me doing my best to get lost!

Check out my latest adventures on Vimeo!